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History of the Discovery of Gabapentin (Neurontin) Treatment of Neuropathic Pain

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Neurontin Chemical Diagram

Neurontin Capsules in Foil Packets
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Early History of the Use of Gabapentin (Neurontin) For CRPS Type I and Neuropathic Pain

A Letter of Appreciation From the First Pain Patient Treated with Gabapentin

How it all began...May 20, 1994

My RSD By Sally S.                                                                       

Reflex sympathetic dystrophy has been my constant companion for the past two and one half years of my life. I fell on my basement steps on November 21, 1991 and since then my life has changed. Up until then, I thought that being a college educator would be the most demanding challenge of my life. Little did I realize after six months and six physicians later when I finally learned my diagnosis, that I was about to travel down a long, rocky road of pain and suffering, sleepless nights, crying and many hours of vigorous physical and occupational therapy to my arm, wrist and hand.
     Following my diagnosis, my therapy consisted of stellate ganglion blocks, TENS unit therapy, repeated peripheral anesthetic nerve blocks and a list of prescribed medications that barely took my pain away. A bone scan confirmed my dismay when the burning pain spread to my left arm. After being treated by Dr. Mellick for over one year, something miraculous happened to me on Friday, May 20, 1994, when I took my first gabapentin capsule at 5 PM. Within two hours after taking my first 300 mg capsule, I felt complete pain relief. This was followed by six hours of beautiful uninterrupted sleep and when I awoke, I was exhilarated over the magnitude of my pain relief. Of course, as with most medications, I experienced side effects. Initially these were euphoria, mild disorientation, dizziness, and drowsiness. They gradually resolved over a few days. Nevertheless, the most amazing thing of all was that my pain racked body was now becoming less sensitive to light touch and by day ten of gabapentin therapy, I was able to hold my grand nephew in my arms for the first time. (Of course I cried). Finger movements had increased dramatically by day fifteen of therapy and occupational therapy was now much less painful and my myofascial treatments were more effective. Follow-up examinations with Dr. Gary Mellick showed that I had much less tenderness to touch and by one month after starting gabapentin, I was able to firmly shake hands with his office staff and experience no pain. My skin texture is normalizing, and my strength is gradually improving. Best of all, my family reports that I am now back to my former self. The awful depression has lifted and I am once again becoming an active participant in life. I am free at last. I am no longer a prisoner in my own body!
     Although I realize that not every one of you who read this will experience the same relief that this medication has afforded me, I still hope and pray that your response is as complete as mine. Thank God! At last there is hope for those of us who suffer with reflex sympathetic dystrophy.

 


GARY AND LARRY MELLICK PUBLISH THE FIRST REPORTS OF GABAPENTIN TREATMENT OF NEUROPATHIC PAIN AND REFLEX SYMPATHETIC DYSTROPHY IN MAY 1995

 

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First Phantom Limb Pain Treatment with Gabapentin by Dr. Mellick

The First Successful Treatment of Postherpetic Neuralgia and Trigeminal Neuralgia with Gabapentin by Dr. Gary Mellick

 


Gabapentin Treatment of RSD Article

 


NEW PROPOSED PAIN TREATMENTS USING GABAPENT IN 1996 MANY OF WHICH DR. MELLICK FIRST TREATED

 

Gabapentin Treatment for Neuropathic Pain: Early Animal Research
 

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